The State Fire Marshall's Office told media outlets that crews from Scio, Jewett and Cadiz responded to the Clearfork Road residence at around 7:00 a.m., and spent much of the morning battling the blaze. Officials said that one woman was flown to a Pittsburgh burn center, while two others were transported to an area hospital.
While few other details have been released, neighbors said that a man, woman and two children lived in the house.
It's still unclear how the early-morning fire began. The State Fire Marshall's Office said an investigation is ongoing.